Reverse Translation
نویسندگان
چکیده
منابع مشابه
Lessons from Reverse Translation
Like many scientists, I sometimes stumble when faced with the cocktail party question—“So what exactly do you study?” After muttering something along the lines of, “basic mechanisms of virus evolution,” the discussion often moves on to the safer ground of politics or religion. As a physician-scientist, I often feel an extra layer of guilt in describing my work, as though I am supposed to be stu...
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In contrast, reverse translation, also called bedside-tobenchtop research, begins with actual, real-life patient experiences in the clinic, or during a clinical trial, and works backward to uncover the mechanistic basis for these experiences and clinical observations. In the reverse translation paradigm, research becomes a seamless, continuous, cyclical process, in which each new patient observ...
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Observation of a clinical event can spur reflective thinking on its source. In pharmacology, adverse events are examples of observations for which deriving the cause is important. Moving from observation to mechanistic understanding requires the use of tools that explicitly delineate biological systems, mode of action, and disease pathophysiology. By expanding understanding of biological factor...
متن کاملReverse Translation in Tuberculosis: Neutrophils Provide Clues for Understanding Development of Active Disease
Tuberculosis (TB) is a major health issue globally. Although typically the disease can be cured by chemotherapy in all age groups, and prevented in part in newborn by vaccination, general consensus exists that development of novel intervention measures requires better understanding of disease mechanisms. Human TB is characterized by polarity between host resistance as seen in 2 billion individu...
متن کاملRibonuclease H-mediated inhibition of translation and reverse transcription by antisense oligodeoxynucleotides.
likely efficacy of antisense oligodeoxynucleotides as chemotherapeutic agents. Two major problems remain. The first of these, as mentioned earlier, is the stability of the ODNs in cell systems. Our present experiments suggest that the half life of these is between 1 and 3 h, which is unlikely to be sufficient for a clinical preparation. The second concerns the efficiency of uptake into the cell...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2018
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.118.313003